The South Congregational Church was established in 1868. It was a formalization of what M. C. Andrews and J. B. Fairfield started in 1852 when they established a Sunday School. Their first minister was Edwards A. Park. While the town of Lawrence continued to grow, so did the church. The congregation moved to larger accommodation accordingly in 1898, a structure which burned down in 1939. When the United Church of Christ formed, South Congregational joined the denomination. As Lawrence's industrial boom grew, so did the number of churches, peaking at 11 at one time. As industry faded, so, too the churches. Many consolidated through mergers or closed in the latter 20th century into the 21st century. South Congregational was not immune to this phenomena. Over the years as the membership shrank, the congregation shared their space other denominations, such as King Baptist Church, Adventist, and Assembly of God. In 2013 the church started to investigate the viability of remaining open. The stop-gap of selling the building was not enough to keep the momentum going and the church decided to close, which they did February 14, 2015.