The Hanover church was organized in 1822, and out of that grew the Salem Street church. Salem church had 32 male and 66 female members, of these 77 came from the Hanover Church. The building was dedicated in 1827, measured 74 by 71 feet, with 134 pews on the lower floor and 32 in the gallery. They were at a disadvantage to other churches in the Boston area because they did not have a permanent clergyman to lead them, until George Blagden finally accepted their offer, possibly in 1830.

During Reverend Blagden’s almost six-year term at the Salem Street Church, the congregation grew by 275 people. His wife started the juvenile society and maternal meetings at the church. After his term in 1837, a new pastor was elected, Joseph H. Towne. In 1842 alone, 153 people were welcomed into the church under Towne’s pastorship. Edward Beecher was then installed as pastor in 1844.

During Edward Beecher’s pastorship, the church building underwent a series of renovations from 1844-1852, and cost $13,500. There was no pastor for a while after his resignation, but then George W. Field took the pulpit from 1856-1862. After the renovations were completed, there were discussions about selling the church in 1866, because there was no permanent minister to lead the services.

Mariners' Church was formed in 1823, and they too had trouble keeping a permanent pastor. It was renamed to the Green Street Church in 1826, and then renamed again back to the Mariners Church in 1830. There were 4 ministers that represented the Mariners' Church; William Jenks, Stephen Bailey, Jonathan Greenleaf, and D. M. Lord.

The Salem Street Church finally merged with the Mariners' Church in January of 1871, and together formed the Salem and Mariners' Church. They sold the building to The First Methodist Episcopal Church for the cost of the renovations, which totaled $13,500.

After the merger, the Salem and Mariners' Church occupied the Methodist House on Hanover Street. The church dissolved in 1879.